Blue light irradiation exerts anti-viral and anti-inflammatory properties against herpes simplex virus type 1 infectionArticle Published on 2023-02-012023-07-11 Journal: Journal of photochemistry and photobiology. B, Bio [Category] COVID19(2023년), [키워드] Blue light herpes simplex virus-1 inflammatory factors viral replication. [DOI] 10.1016/j.jphotobiol.2022.112632 PMC 바로가기
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studiesCOVID-19 위험에 대한 감수성 증가에 기여하는 요인 식별: 멘델식 무작위 배정 연구의 체계적인 검토Article Published on 2022-08-102022-09-11 Journal: International Journal of Epidemiology [Category] 유전자 메커니즘, [키워드] ABO analyses Anthropometrics association assumption attributes Biomarkers Bipolar disorder cardiometabolic disease cardiometabolic diseases Chronic kidney disease contributing to coronavirus disease Coronavirus disease 2019 COVID-19 deficit disease disorder drug English evaluated Evidence Factor Factors fibrosis Genetic help higher risk Hospitalization hyperactivity identify identifying Idiopathic pulmonary fibrosis IL-6 inception Increases increases in Inflammatory factor inflammatory factors interleukin Intervention ischaemic stroke Kidney disease mendelian randomization Mendelian randomization studies Mendelian randomization study OAS1 obesity outcome predicted predisposition protein expression proteomic pulmonary fibrosis risk Schizophrenia searched selected severity smoking socio-demographic suggested susceptibility systematic review systematic review. target targets treating COVID-19 Vitamin D [DOI] 10.1093/ije/dyac076 PMC 바로가기 [Article Type] Article
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathologyCOVID-19 관련 세포 면역 병리학에서 sMAdCAM 및 IL-15의 반대 역할Article Published on 2022-06-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Activation Adhesion Molecule association Asymptomatic Asymptomatic cases CD4+ CD8 Cell cell adhesion molecule cellular characterized circulating Cohort correlated COVID COVID-19 COVID-19 pathology cytokine disease Disease progression duration of hospitalization dysfunction dysregulation effector memory ELISA evaluated Factors flow cytometry Frequency healthy control healthy controls homeostasis homeostatic hypoxemic IL-15 IL-6 IL-6 level IL-6 levels immune increase in India infected individuals Inflammatory factor inflammatory factors intermediate monocytes involved lymphocyte lymphopenia marker Mild moderate moderate to severe monocyte Monocytes mucosal multiparametric flow cytometry Mumbai Pathogenesis pathology plasma profiles quantified recruited regulatory T cells SARS-CoV-2 SARS-CoV-2 infected individual SARS-CoV-2 infected individuals severe disease sMAdCAM. Stage subset symptomatic individual symptomatic individuals symptomatic infection T cells was used while [DOI] 10.1002/JLB.3COVBCR0621-300R PMC 바로가기 [Article Type] Article
The expression patterns of MALAT-1, NEAT-1, THRIL, and miR-155-5p in the acute to the post-acute phase of COVID-19 diseaseCOVID-19 질병의 급성기에서 후기 급성기 MALAT1, NEAT1, THRILL 및 miR-155-5p의 발현 패턴Article Published on 2022-05-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] acute COVID-19 acute phase addition Analysis Biomarker COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 infection diagnose diagnosis of COVID-19 disease evaluated expression level expression levels expression pattern expression patterns hallmark hallmarks healthy control healthy individual Infection Inflammation Inflammatory factor inflammatory factors Long Long non-coding RNAs MicroRNAs microRNAs. miR-150 miR-155 MONITOR mononuclear cell ncRNA ncRNAs non-coding RNA Non-coding RNAs Pathogenesis pathogenesis of COVID-19 Patient PBMC peripheral Peripheral blood real-time PCR assay RNA ROC Curve selected severity of COVID-19 significantly increased significantly lower the SARS-CoV-2 THRIL Total total RNA [DOI] 10.1016/j.bjid.2022.102354 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
Circulating Microparticles in the Pathogenesis and Early Anticoagulation of Thrombosis in COVID-19 With Kidney InjuryCell and Developmental Biology Published on 2022-01-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] abnormality Activation Acute kidney injury affecting aggravate anticoagulant therapy anticoagulation Apoptosis binding site Blood blood cell blood circulation blood flow velocity can be used caused cells circulating clinical manifestations clinical outcomes clinical study Coagulation coagulation cascade Coagulopathy complexes Complexes consequence COVID-19 COVID-19 infection cytokine damaged cells dead Diseases early anticoagulation endothelial injury hospital hypercoagulability Immune cell impaired function IMPROVE inflammatory factors Injury kidney Kidney injury mechanism membrane Microparticle Mortality oxygen pandemic pathophysiological mechanism Patient Perspective Phosphatidylserine platform predict progression Prophylactic provide reduce rehabilitation released renal resulting risk factor thrombosis Treatment Vascular vascular endothelial cells viruses [DOI] 10.3389/fcell.2021.784505 PMC 바로가기 [Article Type] Cell and Developmental Biology
The Interaction Between Pulmonary Fibrosis and COVID-19 and the Application of Related Anti-Fibrotic DrugsPharmacology Published on 2022-01-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute exacerbation acute respiratory distress Affect application ARDS contagious COVID-19 COVID-19 disease Critically ill patient current Cytokine storm Cytokine storms drug drugs fibrosis healthy higher risk Immune cell inflammatory factors Interaction Interstitial lung disease IPF Lungs mechanism mechanisms MOST Pathogenesis pathway Patient patients patients with COVID-19 potential mechanism pulmonary pulmonary fibrosis Respiratory disease Respiratory failure risk risk factor shown syndrome Treatment variety [DOI] 10.3389/fphar.2021.805535 PMC 바로가기 [Article Type] Pharmacology
Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID-19) by suppressing the NF-κB signaling pathwayYindan Jiedu 과립은 NF-κB 신호 전달 경로를 억제하여 신종 코로나바이러스 감염증(COVID-19) 환자에서 항염증 효과를 나타냅니다.Randomized Controlled Trial Published on 2022-01-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, 임상, [키워드] accompanied Activation acute lung injury amyloid A Analysis animals anti-inflammatory effect Anti-inflammatory effects assigned caused CD4 cells clinical Clinical research Compound compounds control group coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 progression Cytokines death decrease disease dissipation docking Effect enrichment analysis erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Factor Granule high-performance liquid chromatography histological HPLC IL-1β IL-6 immune in vitro increase in Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines inflammatory factors inhibit inhibiting Interaction IκBα kaempferol lesion Ligand ligands lipopolysaccharide lung Lung injury Luteolin mass spectrometry mechanism mechanism of action molecular docking Negative conversion network model NF-κB NF-κB pathway NF-κB signaling NF-κB signaling pathway nuclear translocation nucleic acid overlapping p65 pandemic participant pathway Patient Pharmacology Pharmacology analysis Phosphorylation progression propensity score matching PSM quercetin Randomly recruited sedimentation rate serum serum amyloid significantly strong interaction suppressed T cell Tandem mass spectrometry target targets therapeutic effect therapeutic effects TNF-α viral nucleic acid were measured Yindan jiedugranules. [DOI] 10.1016/j.phymed.2021.153784 PMC 바로가기 [Article Type] Randomized Controlled Trial
The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case-control studyClinical Trial Published on 2021-12-012022-10-05 Journal: Inflammopharmacology [Category] 임상, [키워드] age analyzed Appetite blood sample case-control study clinical status control group COVID-19 COVID-19 patient COVID-19 patients FIVE Gender Glutamine Health hospital IL1β IMPROVE increase inflammatory factors L-Glutamine Malnutrition oxidative stress oxidative stress. Patient per day receive reduce reduced reducing respiratory infection Serum level significant increase significantly Stress therapy total antioxidant capacity Treatment tumor necrosis factor-α [DOI] 10.1007/s10787-021-00881-0 PMC 바로가기 [Article Type] Clinical Trial